Susceptibility of Rats to Mammary Gland Carcinogenesis by the Food-Derived Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP) Varies with Age and Is Associated with the Induction of Differential Gene Expression

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic amine found in cooked meat, induces mammary gland cancer when administered to adolescent female rats (43-day-old). In contrast, mature virgin rats (150-day-old) were resistant to mammary carcinogenesis by PhIP. To explore the pos...

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Autores principales: Shan, Liang, Yu, Minshu, Schut, Herman A.J., Snyderwine, Elizabeth G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2004
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618529/
https://ncbi.nlm.nih.gov/pubmed/15215175
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