Detection of Nucleotide Variability in rpoB in both Rifampin-Sensitive and Rifampin-Resistant Strains of Chlamydia trachomatis

A 656-bp PCR fragment from rpoB was sequenced from five rifampin-resistant Chlamydia trachomatis variants selected in vitro from a wild-type parent with a surprising level of genetic variability in this region. Three variants (MIC, 4 μg/ml) showed Ala522→Val in cluster I (codons 507 to 533), which h...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Dreses-Werringloer, Ute, Padubrin, Ingrid, Köhler, Lars, Hudson, Alan P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161851/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821487/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.7.2316-2318.2003
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