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Pharmacokinetics-Pharmacodynamics of Rifampin in an Aerosol Infection Model of Tuberculosis

Limited information exists on the pharmacokinetic (PK)-pharmacodynamic (PD) relationships of drugs against Mycobacterium tuberculosis. Our aim was to identify the PK-PD parameter that best describes the efficacy of rifampin on the basis of in vitro and PK properties. Consistent with 83.8% protein bi...

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Published in:Antimicrob Agents Chemother
Main Authors: Jayaram, Ramesh, Gaonkar, Sheshagiri, Kaur, Parvinder, Suresh, B. L., Mahesh, B. N., Jayashree, R., Nandi, Vrinda, Bharat, Sowmya, Shandil, R. K., Kantharaj, E., Balasubramanian, V.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2003
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161844/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12821456/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.7.2118-2124.2003
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