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Regulation of TopBP1 oligomerization by Akt/PKB for cell survival
Regulation of E2F1-mediated apoptosis is essential for proper cellular growth. This control requires TopBP1, a BRCT (BRCA1 carboxyl-terminal) domain-containing protein, which interacts with E2F1 but not other E2Fs and represses its proapoptotic activity. We now show that the regulation of E2F1 by To...
Sparad:
| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2006
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1618094/ https://ncbi.nlm.nih.gov/pubmed/17006541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601355 |
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