MDMA-induced neurotoxicity: long-term effects on 5-HT biosynthesis and the influence of ambient temperature

1. 3,4-Methylenedioxymethamphetamine (MDMA or ‘ecstasy') decreases the 5-HT concentration, [(3)H]-paroxetine binding and tryptophan hydroxylase activity in rat forebrain, which has been interpreted as indicating 5-HT neurodegeneration. This has been questioned, particularly the 5-HT loss, as MD...

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Main Authors: O'shea, Esther, Orio, Laura, Escobedo, Isabel, Sanchez, Veronica, Camarero, Jorge, Green, Alfred Richard, Colado, Maria Isabel
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2006
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Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617070/
https://ncbi.nlm.nih.gov/pubmed/16770327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706783
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