Inhibition of Na(+)/H(+)-exchanger with sabiporide attenuates the downregulation and uncoupling of the myocardial β-adrenoceptor system in failing rabbit hearts

1. Chronic heart failure (HF) is characterized by left ventricular (LV) structural remodeling, impaired function, increased circulating noradrenaline (NA) levels and impaired responsiveness of the myocardial β-adrenoceptor (βAR)-adenylyl cyclase (AC) system. In failing hearts, inhibition of the sodi...

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Detalhes bibliográficos
Main Authors: Leineweber, Kirsten, Aker, Stephanie, Beilfuß, Anja, Rekasi, Heike, Konietzka, Ina, Martin, Claus, Heusch, Gerd, Schulz, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2006
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1617059/
https://ncbi.nlm.nih.gov/pubmed/16520740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706714
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