Purification and Characterization of a Monooxygenase Involved in the Biosynthetic Pathway of the Antitumor Drug Mithramycin

A monooxygenase encoded by the mtmOIV gene from the mithramycin gene cluster of Streptomyces argillaceus was purified 21-fold by a three-step purification procedure. This monooxygenase catalyzes the oxidative cleavage of the fourth ring of premithramycin B. The enzyme was dependent on NADPH and flav...

ver descrição completa

Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Rodríguez, David, Quirós, Luis M., Braña, Alfredo F., Salas, José A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2003
Assuntos:	Enzymes and Proteins
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC161570/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12813091/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.185.13.3962-3965.2003
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!