Retention of the Arginine Allele in Codon 72 of the p53 Gene Correlates with Poor Apoptosis in Head and Neck Cancer

The allele constitution at codon 72 of the p53 gene (CGC-arginine or CCC-proline) plays a major role in inducing apoptosis in p53 mutant cells. To verify this, we determined GC-status, p53-mutations, and p53-loss of heterozygosity (LOH) in a group of 54 squamous cell carcinomas of the head and neck...

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Autores principales: Schneider-Stock, Regine, Mawrin, Christian, Motsch, Christiane, Boltze, Carsten, Peters, Brigitte, Hartig, Roland, Buhtz, Peter, Giers, Anja, Rohrbeck, Astrid, Freigang, Bernd, Roessner, Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615339/
https://ncbi.nlm.nih.gov/pubmed/15039212
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