Structure-Function Relationship in a Variant Hemoglobin: A Combined Computational-Experimental Approach

Our study examines the functional and structural effects of amino acid substitution in the distal side of β-chains of human Hb Duarte ([Formula: see text]). We have compared the functional properties of the purified Hb Duarte with those of HbA, and through proton NMR and molecular dynamics simulatio...

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Bibliografski detalji
Glavni autori: Ceccarelli, Matteo, Ruggerone, Paolo, Anedda, Roberto, Fais, Antonella, Era, Benedetta, Sollaino, Maria Carla, Corda, Marcella, Casu, Mariano
Format: Artigo
Jezik:Inglês
Izdano: Biophysical Society 2006
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1614504/
https://ncbi.nlm.nih.gov/pubmed/16844744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.083170
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