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Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments

BACKGROUND: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, divergences and tools, and further how this variation impacts specific inferences, remains unclear. RESULTS: Here we devel...

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Bibliografische gegevens
Hoofdauteurs: Pollard, Daniel A, Moses, Alan M, Iyer, Venky N, Eisen, Michael B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2006
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1613255/
https://ncbi.nlm.nih.gov/pubmed/16904011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-7-376
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