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Effect of cirrhosis of the liver on the pharmacokinetics of chlormethiazole.

The pharmacokinetics of chlormethiazole were studied in eight patients with advanced cirrhosis of the liver and in six healthy volunteers after oral and intravenous administration of the drug. In the patients the systemic bioavailability of oral chlormethiazole was increased about tenfold, whereas i...

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Bibliographic Details
Main Authors: Pentikainen, P J, Neuvonen, P J, Tarpila, S, Syvälahti, E
Format: Artigo
Language:Inglês
Published: 1978
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1607958/
https://ncbi.nlm.nih.gov/pubmed/709096
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