Toxoplasma gondii Prevents Neuron Degeneration by Interferon-γ-Activated Microglia in a Mechanism Involving Inhibition of Inducible Nitric Oxide Synthase and Transforming Growth Factor-β1 Production by Infected Microglia

Interferon (IFN)-γ, the main cytokine responsible for immunological defense against Toxoplasma gondii, is essential in all infected tissues, including the central nervous system. However, IFN-γ-activated microglia may cause tissue injury through production of toxic metabolites such as nitric oxide (...

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Main Authors: Rozenfeld, Claudia, Martinez, Rodrigo, Seabra, Sérgio, Sant’Anna, Celso, Gonçalves, J. Gabriel R., Bozza, Marcelo, Moura-Neto, Vivaldo, De Souza, Wanderley
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2005
Fag:
Original Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603680/
https://ncbi.nlm.nih.gov/pubmed/16192637
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