Constitutive Activation of JAK3/STAT3 in Colon Carcinoma Tumors and Cell Lines : Inhibition of JAK3/STAT3 Signaling Induces Apoptosis and Cell Cycle Arrest of Colon Carcinoma Cells

Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The biological effects of STAT3 have not been studied extensively in the pathogenesis of colon cancer, nor has the role of Janus kinase 3 (JAK3), the physiological activator of STAT3, been evaluated. Here, we demonst...

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Bibliografiske detaljer
Main Authors: Lin, Quan, Lai, Raymond, Chirieac, Lucian R., Li, Changping, Thomazy, Vilmos A., Grammatikakis, Ioannis, Rassidakis, George Z., Zhang, Wei, Fujio, Yasushi, Kunisada, Keita, Hamilton, Stanley R., Amin, Hesham M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2005
Fag:
Original Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603671/
https://ncbi.nlm.nih.gov/pubmed/16192633
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