Inhibition of Tumor Necrosis Factor-α Improves Physiological Angiogenesis and Reduces Pathological Neovascularization in Ischemic Retinopathy

The present study was undertaken to test whether inhibition of the proangiogenic inflammatory cytokine tumor necrosis factor (TNF)-α can modulate retinal hypoxia and preretinal neovascularization in a murine model of oxygen-induced retinopathy (OIR). OIR was produced in TNF-α−/− and wild-type (WT) c...

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Главные авторы: Gardiner, Tom A., Gibson, David S., de Gooyer, Tanyth E., de la Cruz, Vidal F., McDonald, Denise M., Stitt, Alan W.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Investigative Pathology 2005
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Original Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602321/
https://ncbi.nlm.nih.gov/pubmed/15681845
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