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Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease

Caspase-3 is an effector of apoptosis in experimental models of Parkinson's disease (PD). However, its potential role in the human pathology remains to be demonstrated. Using caspase-3 immunohistochemistry on the postmortem human brain, we observed a positive correlation between the degree of neuron...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hartmann, Andreas, Hunot, Stéphane, Michel, Patrick P., Muriel, Marie-Paule, Vyas, Sheela, Faucheux, Baptiste A., Mouatt-Prigent, Annick, Turmel, Hélène, Srinivasan, Anu, Ruberg, Merle, Evan, Gerard I., Agid, Yves, Hirsch, Etienne C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16023/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688892/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040556597
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