Increased Expression of Plasminogen Activator Inhibitor-1 in Cardiomyocytes Contributes to Cardiac Fibrosis after Myocardial Infarction

Plasminogen activator inhibitor-1 (PAI-1) plays a critical role in tissue fibrosis by inactivating matrix metalloproteinases, which might effect on the progression of left ventricular dysfunction. However, little has been known about the expression of PAI-1 during cardiac remodeling. We used a mouse...

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Detalhes bibliográficos
Main Authors: Takeshita, Kyosuke, Hayashi, Mutsuharu, Iino, Shigeo, Kondo, Takahisa, Inden, Yasuya, Iwase, Mitsunori, Kojima, Tetsuhito, Hirai, Makoto, Ito, Masafumi, Loskutoff, David J., Saito, Hidehiko, Murohara, Toyoaki, Yamamoto, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2004
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602257/
https://ncbi.nlm.nih.gov/pubmed/14742251
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