Retinal Dystrophy Resulting from Ablation of RXRα in the Mouse Retinal Pigment Epithelium

Vitamin A (retinol) actions in eye development are mediated by retinoic acid receptors (RARs and RXRs). Using the Cre/loxP system, we have selectively ablated RXRα in the retinal pigment epithelium (RPE), a cell monolayer critically involved in visual retinoid renewal and phagocytosis of photorecept...

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Main Authors: Mori, Mikiro, Metzger, Daniel, Picaud, Serge, Hindelang, Colette, Simonutti, Manuel, Sahel, José, Chambon, Pierre, Mark, Manuel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2004
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602254/
https://ncbi.nlm.nih.gov/pubmed/14742273
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