Valproic Acid, an Antiepileptic Drug with Histone Deacetylase Inhibitory Activity, Potentiates the Cytotoxic Effect of Apo2L/TRAIL on Cultured Thoracic Cancer Cells through Mitochondria-Dependent Caspase Activation

Inhibitors of histone deacetylases have been shown to enhance the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand TRAIL-mediated cytotoxicity. Valproic acid (VA), a commonly used antiepileptic agent whose pharmacokinetics and toxicity profiles are well describe...

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Autors principals: Ziauddin, M Firdos, Yeow, Wen-Shuz, Maxhimer, Justin B, Baras, Aris, Chua, Alex, Reddy, Rishindra M, Tsai, Wilson, Cole, George W, Schrump, David S, Nguyen, Dao M
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1601472/
https://ncbi.nlm.nih.gov/pubmed/16820090
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