The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer

The MEK-ERK growth signaling pathway is important in human hepatocellular carcinoma (HCC). To evaluate the targeting of this pathway in HCC, we characterized a novel, orally-active MEK inhibitor, PD184161, using human HCC cells (HepG2, Hep3B, PLC, and SKHep) and in vivo human tumor xenografts. PD184...

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Main Authors: Klein, Patrick J, Schmidt, C Max, Wiesenauer, Chad A, Choi, Jennifer N, Gage, Earl A, Yip-Schneider, Michele T, Wiebke, Eric A, Wang, Yufang, Omer, Charles, Sebolt-Leopold, Judith S
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1601146/
https://ncbi.nlm.nih.gov/pubmed/16533420
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