Viral persistence in vivo through selection of neutralizing antibody-escape variants

Despite initial virus control by CD8(+) cytotoxic T lymphocytes (CTLs), noncytopathic or variably cytopathic viruses (e.g., hepatitis B and C viruses, HIV) are able to establish persistent infections. The role of neutralizing antibodies (nAbs) in controlling disease progression is unclear. Therefore...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ciurea, Adrian, Klenerman, Paul, Hunziker, Lukas, Horvath, Edit, Senn, Beatrice M., Ochsenbein, Adrian F., Hengartner, Hans, Zinkernagel, Rolf M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16001/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688894/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040558797
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