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The Role of Compensatory Mutations in the Emergence of Drug Resistance
Pathogens that evolve resistance to drugs usually have reduced fitness. However, mutations that largely compensate for this reduction in fitness often arise. We investigate how these compensatory mutations affect population-wide resistance emergence as a function of drug treatment. Using a model of...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1599768/ https://ncbi.nlm.nih.gov/pubmed/17040124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020137 |
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