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The Role of Compensatory Mutations in the Emergence of Drug Resistance

Pathogens that evolve resistance to drugs usually have reduced fitness. However, mutations that largely compensate for this reduction in fitness often arise. We investigate how these compensatory mutations affect population-wide resistance emergence as a function of drug treatment. Using a model of...

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Autors principals: Handel, Andreas, Regoes, Roland R, Antia, Rustom
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599768/
https://ncbi.nlm.nih.gov/pubmed/17040124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020137
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