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Comparison of intravenous and oral high-dose methotrexate in treatment of solid tumours.

An outpatient regimen of oral high-dose methotrexate was studied in 14 patients with solid tumours over 12 months. Detailed pharmacokinetic analysis in five patients showed high oral bioavailability (mean +/- SE of mean 87.6 +/- 1.5%), indicating that with this regimen oral methotrexate was well abs...

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Detalhes bibliográficos
Main Authors: Christophidis, N, Vajda, F J, Lucas, I, Moon, W J, Louis, W J
Formato: Artigo
Idioma:Inglês
Publicado em: 1979
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1597710/
https://ncbi.nlm.nih.gov/pubmed/421088
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