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Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ

Pleiotrophin (PTN) is a platelet-derived growth factor-inducible, 18-kDa heparin-binding cytokine that signals diverse phenotypes in normal and deregulated cellular growth and differentiation. To seek the mechanisms of PTN signaling, we studied the interactions of PTN with the receptor protein tyros...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Meng, Kung, Rodríguez-Peña, A., Dimitrov, Todor, Chen, Wen, Yamin, Moshe, Noda, Masaharu, Deuel, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15975/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10706604/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.020487997
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