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The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure

The question of whether a protein whose natural sequence is inverted adopts a stable fold is still under debate. We have determined the 2.1-Å crystal structure of the retro-GCN4 leucine zipper. In contrast to the two-stranded helical coiled-coil GCN4 leucine zipper, the retro-leucine zipper formed a...

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Autori principali: Mittl, Peer R. E., Deillon, Christine, Sargent, David, Liu, Niankun, Klauser, Stephan, Thomas, Richard M., Gutte, Bernd, Grütter, Markus G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC15968/
https://ncbi.nlm.nih.gov/pubmed/10716989
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