The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates

Enterobactin, the tris-(N-(2,3-dihydroxybenzoyl)serine) trilactone siderophore of Escherichia coli, is synthesized by a three-protein (EntE, B, F) six-module nonribosomal peptide synthetase (NRPS). In this work, the 142-kDa four-domain protein EntF was bisected into two double-domain fragments: a 10...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Ehmann, David E., Shaw-Reid, Cathryn A., Losey, Heather C., Walsh, Christopher T.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15959/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688898/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040572897
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