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The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism

Nitric oxide (NO) was found to inhibit the copper-dependent induction of the yeast CUP1 gene. This effect is attributable to an inhibition of the copper-responsive CUP1 transcriptional activator Ace1. A mechanism is proposed whereby the metal binding thiols of Ace1 are chemically modified via NO- an...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Shinyashiki, Masaru, Chiang, Kenneth T., Switzer, Christopher H., Gralla, Edith B., Valentine, Joan S., Thiele, Dennis J., Fukuto, Jon M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15956/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10694579/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.050586597
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