Mutations within the Catalytic Motif of DNA Adenine Methyltransferase (Dam) of Aeromonas hydrophila Cause the Virulence of the Dam-Overproducing Strain To Revert to That of the Wild-Type Phenotype

In this study, we demonstrated that the methyltransferase activity associated with Dam was essential for attenuation of Aeromonas hydrophila virulence. We mutated aspartic acid and tyrosine residues to alanine within the conserved DPPY catalytic motif of Dam and transformed the pBAD/dam(D/A), pBAD/d...

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Bibliographic Details
Main Authors: Erova, Tatiana E., Fadl, Amin A., Sha, Jian, Khajanchi, Bijay K., Pillai, Lakshmi L., Kozlova, Elena V., Chopra, Ashok K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594908/
https://ncbi.nlm.nih.gov/pubmed/16988254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00994-06
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