Constitutive ALK5-Independent c-Jun N-Terminal Kinase Activation Contributes to Endothelin-1 Overexpression in Pulmonary Fibrosis: Evidence of an Autocrine Endothelin Loop Operating through the Endothelin A and B Receptors

The signal transduction mechanisms generating pathological fibrosis are almost wholly unknown. Endothelin-1 (ET-1), which is up-regulated during tissue repair and fibrosis, induces lung fibroblasts to produce and contract extracellular matrix. Lung fibroblasts isolated from scleroderma patients with...

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Main Authors: Shi-Wen, Xu, Rodríguez-Pascual, Fernando, Lamas, Santiago, Holmes, Alan, Howat, Sarah, Pearson, Jeremy D., Dashwood, Michael R., du Bois, Roland M., Denton, Christopher P., Black, Carol M., Abraham, David J., Leask, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592704/
https://ncbi.nlm.nih.gov/pubmed/16809784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00625-06
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