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Abnormalities of Germ Cell Maturation and Sertoli Cell Cytoskeleton in Androgen Receptor 113 CAG Knock-In Mice Reveal Toxic Effects of the Mutant Protein

An unresolved question in the study of the polyglutamine neurodegenerative disorders is the extent to which partial loss of normal function of the mutant protein contributes to the disease phenotype. To address this, we studied Kennedy disease, a degenerative disorder of lower motor neurons caused b...

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Autors principals: Yu, Zhigang, Dadgar, Nahid, Albertelli, Megan, Scheller, Arno, Albin, Roger L., Robins, Diane M., Lieberman, Andrew P.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592669/
https://ncbi.nlm.nih.gov/pubmed/16400023
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