LRRK2 G2019S in Families with Parkinson Disease Who Originated from Europe and the Middle East: Evidence of Two Distinct Founding Events Beginning Two Millennia Ago

The leucine-rich repeat kinase 2 (LRRK2) G2019S mutation is the most common genetic determinant of Parkinson disease (PD) identified to date. It accounts for 1%–7% of PD in patients of European origin and 20%–40% in Ashkenazi Jews and North African Arabs with PD. Previous studies concluded that pati...

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Hauptverfasser: Zabetian, Cyrus P., Hutter, Carolyn M., Yearout, Dora, Lopez, Alexis N., Factor, Stewart A., Griffith, Alida, Leis, Berta C., Bird, Thomas D., Nutt, John G., Higgins, Donald S., Roberts, John W., Kay, Denise M., Edwards, Karen L., Samii, Ali, Payami, Haydeh
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society of Human Genetics 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592578/
https://ncbi.nlm.nih.gov/pubmed/16960813
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