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The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A

Proteolytic cleavage of the six known insulin-like growth factor binding proteins (IGFBPs) is a powerful means of rapid structure and function modification of these important growth-regulatory proteins. Intact IGFBP-4 is a potent inhibitor of IGF action in vitro, and cleavage of IGFBP-4 has been sho...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lawrence, James B., Oxvig, Claus, Overgaard, Michael T., Sottrup-Jensen, Lars, Gleich, Gerald J., Hays, Lara G., Yates, John R., Conover, Cheryl A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15910/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077652/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.3149
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