A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing

CapG is the only member of the gelsolin family unable to sever actin filaments. Changing amino acids 84–91 (severing domain) and 124–137 (WH2-containing segment) simultaneously to the sequences of gelsolin results in a mutant, CapG-sev, capable of severing actin filaments. The gain of severing funct...

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Autors principals: Zhang, Y, Vorobiev, Sergey M, Gibson, Bruce G, Hao, Binghua, Sidhu, Gurjit S, Mishra, Vishnu S, Yarmola, Elena G, Bubb, Michael R, Almo, Steven C, Southwick, Frederick S
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1589989/
https://ncbi.nlm.nih.gov/pubmed/16977317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601323
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