Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene

Heterozygosity for germ-line mutations in the DNA mismatch repair gene MSH2 predisposes humans to cancer. Here we use a highly sensitive reporter to describe a spontaneous mutator phenotype in diploid yeast cells containing a deletion of only one MSH2 allele. We also identify five MSH2 missense muta...

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Auteurs principaux: Drotschmann, Karin, Clark, Alan B., Tran, Hiep T., Resnick, Michael A., Gordenin, Dmitry A., Kunkel, Thomas A.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1999
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC15879/
https://ncbi.nlm.nih.gov/pubmed/10077621
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