Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

The human PTEN tumor suppressor gene is mutated in a wide variety of sporadic tumors. To determine the function of PTEN in vivo we have studied a PTEN homolog in Caenorhabditis elegans. We have generated a strong loss-of-function allele of the PTEN homolog and shown that the deficient strain is unab...

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Bibliografiska uppgifter
Huvudupphovsmän: Gil, Elad B., Malone Link, Elizabeth, Liu, Leo X., Johnson, Carl D., Lees, Jacqueline A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 1999
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC15871/
https://ncbi.nlm.nih.gov/pubmed/10077613
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