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Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences

We have taken a comprehensive approach to the generation of novel DNA binding zinc finger domains of defined specificity. Herein we describe the generation and characterization of a family of zinc finger domains developed for the recognition of each of the 16 possible 3-bp DNA binding sites having t...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Segal, David J., Dreier, Birgit, Beerli, Roger R., Barbas, Carlos F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15842/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077584/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.2758
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