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In vitro suicide inhibition of self-splicing of a group I intron from Pneumocystis carinii by an N3′ → P5′ phosphoramidate hexanucleotide

Binding enhancement by tertiary interactions is a strategy that takes advantage of the higher order folding of functionally important RNAs to bind short nucleic acid-based compounds tightly and more specifically than possible by simple base pairing. For example, tertiary interactions enhance binding...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Testa, Stephen M., Gryaznov, Sergei M., Turner, Douglas H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1999
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC15838/
https://ncbi.nlm.nih.gov/pubmed/10077580
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