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Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer

Excitatory synaptic activity can evoke transient and substantial elevations of postsynaptic calcium. Downstream effects of elevated calcium include the activation of the calcium-dependent protease calpain. We have developed a reagent that identifies dendritic spines in which calpain has been activat...

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Detalhes bibliográficos
Main Authors: Vanderklish, Peter W., Krushel, Leslie A., Holst, Brent H., Gally, Joseph A., Crossin, Kathryn L., Edelman, Gerald M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15787/
https://ncbi.nlm.nih.gov/pubmed/10688895
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