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The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover
Patched (Ptc) is a membrane protein whose function in Hedgehog (Hh) signal transduction has been conserved among metazoans and whose malfunction has been implicated in human cancers. Genetic analysis has shown that Ptc negatively regulates Hh signal transduction, but its activity and structure are n...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1578677/ https://ncbi.nlm.nih.gov/pubmed/16980583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1461306 |
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