(-)-Gossypol Inhibits Growth and Promotes Apoptosis of Human Head and Neck Squamous Cell Carcinoma In Vivo

Resistance to chemotherapy is a common problem encountered in the treatment of head and neck squamous cell carcinoma (HNSCC). Chemoresistant HNSCC tumors frequently overexpress antiapoptotic proteins, such as Bcl-x(L). (-)-Gossypol, the negative enantiomer of a cottonseed polyphenol, binds to Bcl-x(...

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Main Authors: Wolter, Keith G, Wang, Steven J, Henson, Bradley S, Wang, Shaomeng, Griffith, Kent A, Kumar, Bhavna, Chen, Jianyong, Carey, Thomas E, Bradford, Carol R, D'Silva, Nisha J
Format: Artigo
Jezik:Inglês
Izdano: Neoplasia Press Inc. 2006
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578526/
https://ncbi.nlm.nih.gov/pubmed/16611409
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