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Using Metadynamics to Understand the Mechanism of Calmodulin/Target Recognition at Atomic Detail

The ability of calcium-bound calmodulin (CaM) to recognize most of its target peptides is caused by its binding to two hydrophobic residues (‘anchors’). In most of the CaM complexes, the anchors pack against the hydrophobic pockets of the CaM domains and are surrounded by fully conserved Met side ch...

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Autors principals: Fiorin, G., Pastore, A., Carloni, P., Parrinello, M.
Format: Artigo
Idioma:Inglês
Publicat: Biophysical Society 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578468/
https://ncbi.nlm.nih.gov/pubmed/16877506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.086611
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