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IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-γ

IL-18 shares with IL-1 the same family of receptors and several identical signal transduction pathways. Because of these similarities, IL-18 was investigated for its ability to induce prostaglandin E(2) (PGE(2)) synthesis in human peripheral blood mononuclear cells (PBMC), a prominent, proinflammato...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Reznikov, Leonid L., Kim, Soo-Hyun, Westcott, Jay Y., Frishman, Jordan, Fantuzzi, Giamila, Novick, Daniela, Rubinstein, Menachem, Dinarello, Charles A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15773/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681439/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040582597
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