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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia

We have identified a gene at 11q23, telomeric to MLL, that encodes a guanine nucleotide exchange factor (GEF). This gene is transcribed into a 9.5-kb mRNA containing a 4.6-kb ORF. By Northern analysis, it was found to be expressed in all human tissues examined including peripheral blood leukocytes,...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Kourlas, Peter J., Strout, Matthew P., Becknell, Brian, Veronese, Maria Luisa, Croce, Carlo M., Theil, Karl S., Krahe, Ralf, Ruutu, Tapani, Knuutila, Sakari, Bloomfield, Clara D., Caligiuri, Michael A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15768/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681437/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040569197
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