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Meiotic instability of CAG repeat tracts occurs by double-strand break repair in yeast

Expansion of trinucleotide repeats is associated with a growing number of human diseases. The mechanism and timing of expansion of the repeat tract are poorly understood. In humans, trinucleotide repeats show extreme meiotic instability, and expansion of the repeat tract has been suggested to occur...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Jankowski, Craig, Nasar, Farooq, Nag, Dilip K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15766/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681451/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040460297
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