Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats

1. Zanapezil (TAK-147 (3-[1benzylpiperdin-4-yl]-1-(2,3,4,5-tetrahydro-1 H-1-benzazepin-8-yl) propan-1-one fumarate)) is a selective acetylcholine (ACh) esterase inhibitor under investigation as a drug for Alzheimer's disease (AD) treatment. 2. In this study, the effects of TAK-147 at 2 mg kg(−1...

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Detalhes bibliográficos
Main Authors: Hatip-Al-Khatib, Izzettin, Iwasaki, Katsunori, Yoshimitsu, Yoshitaka, Arai, Takashi, Egashira, Nobuaki, Mishima, Kenichi, Ikeda, Tomoaki, Fujiwara, Michihiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576235/
https://ncbi.nlm.nih.gov/pubmed/15951830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706288
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