The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level

1. Cyclosporin A and tacrolimus are clinically important immunosuppressive drugs directly targeting the transcription factor nuclear factor of activated T cells (NFAT). Through inhibition of calcineurin phosphatase activity they block the dephosphorylation and thus activation of NFAT. Cyclosporin A...

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Autors principals: Oetjen, Elke, Thoms, Kai-Martin, Laufer, Yvonne, Pape, Daniela, Blume, Roland, Li, Pingfeng, Knepel, Willhart
Format: Artigo
Idioma:Inglês
Publicat: 2005
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Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576078/
https://ncbi.nlm.nih.gov/pubmed/15711594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706127
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