Deoxycholic acid inhibits pacemaker currents by activating ATP-dependent K(+) channels through prostaglandin E(2) in interstitial cells of Cajal from the murine small intestine

1. We investigated the role of deoxycholic acid in pacemaker currents using whole-cell patch-clamp techniques at 30°C in cultured interstitial cells of Cajal (ICC) from murine small intestine. 2. The treatment of ICC with deoxycholic acid resulted in a decrease in the frequency and amplitude of pace...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jun, Jae Yeoul, Choi, Seok, Chang, In-Youb, Yoon, Cha Kyung, Jeong, Hye-Gwang, Kong, In Deok, So, Insuk, Kim, Ki Whan, You, Ho Jin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2004
Pynciau:
Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575998/
https://ncbi.nlm.nih.gov/pubmed/15665863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706074
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