Prevention of progressive joint destruction in collagen-induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR255031

1. FR255031 (2-[(7S)-7-[5-(4-ethylphenyl)-2-thienyl]-1,1-dioxido-4-(2-pyridinylcarbonyl)hexahydro-1,4-thiazepin-7-yl]-N-hydroxyacetamide) is a novel synthetic matrix metalloproteinase (MMP) inhibitor that inhibits human collagenases (MMP-1, MMP-8 and MMP-13), gelatinases (MMP-2 and MMP-9) and membra...

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Main Authors: Ishikawa, Takeshi, Nishigaki, Fusako, Miyata, Susumu, Hirayama, Yoshitaka, Minoura, Kyoko, Imanishi, Junko, Neya, Masahiro, Mizutani, Tsuyoshi, Imamura, Yoshimasa, Naritomi, Yoichi, Murai, Hidetsugu, Ohkubo, Yoshitaka, Kagayama, Akira, Mutoh, Seitaro
Format: Artigo
Language:Inglês
Published: 2004
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575983/
https://ncbi.nlm.nih.gov/pubmed/15644877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706054
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