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A novel Na(+) channel agonist, dimethyl lithospermate B, slows Na(+) current inactivation and increases action potential duration in isolated rat ventricular myocytes
1. Voltage-gated Na(+) channel blockers have been widely used as local anaesthetics and antiarrhythmic agents. It has recently been proposed that Na(+) channel agonists can be used as inotropic agents. Here, we report the identification of a natural substance that acts as a Na(+) channel agonist. 2....
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1575928/ https://ncbi.nlm.nih.gov/pubmed/15504759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705969 |
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