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Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine

1. The effects of (S)- and (R)-lercanidipine on CHO cells stably expressing the cardiac (Ca(v)1.2a) or vascular (Ca(v)1.2b) splice variant of the L-type calcium channel pore subunit were studied, using whole-cell and single-channel patch-clamp measurements. 2. Lercanidipine block of Ca(v)1.2b curren...

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Detalhes bibliográficos
Main Authors: Wirtz, Susanne, Herzig, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574954/
https://ncbi.nlm.nih.gov/pubmed/15155536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705786
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