R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter

1. Clinical observations with the selective serotonin reuptake inhibitor (SSRI), S-citalopram, indicate that S-citalopram is more efficacious and produces earlier symptom relief than RS-citalopram. Since R-citalopram is at least 20-fold weaker than S-citalopram as inhibitor of the 5-HT transporter (...

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Bibliographic Details
Main Authors: Stórustovu, Signe í, Sánchez, Connie, Pörzgen, Peter, Brennum, Lise T, Larsen, Anna Kirstine, Pulis, Monica, Ebert, Bjarke
Format: Artigo
Language:Inglês
Published: 2004
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574928/
https://ncbi.nlm.nih.gov/pubmed/15037515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705738
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